Navigate the complex and multidisciplinary path of drug discovery procedures with Drug Discovery Strategies and Methods-a well-organized and timely reference that analyzes methods in target identification and validation, lead detection, compound optimization, and biological testing. This volume addresses challenges encountered during the discovery

1 Protein Crystallography in Structure based Drug Design, 2 SRS Homology-2 Domains and Structure-Based, Small Molecule Library Approaches to Drug Discovery, 3Three-Dimensional Structure of the Inhibited Catalytic Domain of Human Stromelysin-1 by Heteronuclear NMR Spectroscopy, 4 Cannabinergics: Old and New Therapeutic Possibilities, 5 Development of PET and SPECT Radioligands for Cannabinoid Receptors, 6 Structural and Pharmacological Aspects of Peptidomimetics, 7 Linkers and Resins for Solid-Phase Synthesis, 8 Allosteric Modulation of G Protein -Coupled Receptors: Implications for Drug Action 9 Protein Misfolding and Neurodegenerative Disease: Therapeutic Opportunities 10 Uncoating and Adsorption Inhibitors of Rhinovirus Replication, 11 Profiles of Prototype Antiviral Agents Interfering with the Initial Stages of HIV Infection