ABSTRACT
Fibrinolysis in Disease reviews the state of the art of basic and clinical aspects of the fibrinolytic enzyme system. The text, authored by outstanding and internationally known investigators, is presented in two books.
The Malignant Process, Interventions in Thrombogenic Mechanisms, and Novel Treatment Modalities discusses the molecular biology of the system's key components and their fundamental roles in a variety of thrombotic and metabolic disorders. Molecular and Hemovascular Aspects of Fybrinolysis presents the latest findings and concepts of the association between plasminogen activator (u-PA) overexpression and abnormal growth regulation in a variety of solid tumors and in leukemia. One chapter deals with various successful interventions in thrombogenic mechanisms, ranging from exercise and diet to anticoagulants and direct and indirect thrombolytic agents. It concludes with a projection of exciting, novel treatment modalities in thrombotic and malignant diseases.
TABLE OF CONTENTS
part Section I|42 pages
Molecular Biology of the Chief Regulators of the Fibrinolytic/Proteolytic Enzyme Systems
part Section II|225 pages
The Role of the Plasminogen Activation System in the Maintenance of Vascular Integrity
part A|36 pages
General Aspects
chapter Chapter 6|10 pages
Normal and Abnormal Endothelial Release of Tissue-Type Plasminogen Activator
part B|189 pages
Fibrinolytic Abnormalities in Various Disease States