ABSTRACT
Surviving Hypoxia: Mechanisms of Control and Adaptation is a synthesis of findings and thoughts concerning hypoxia. The thermodynamics of hypoxia are discussed in detail, including acid-base balance and self-pollution resulting from the accumulation of anaerobic end-products. The book focuses on descriptions and discussions of common facets, contrasting solutions in a variety of physiological hypoxia defense strategies, including those shown by plants, invertebrates, and vertebrates. Special treatment is given to the distinctive problems that hypoxia presents to vulnerable organs such as the kidney, liver, and brain. It also addresses pathological events in addition to protective mechanisms.
Clinical implications of basic research are examined in the book, which provides new insights into underlying pathological processes occuring in hypoxic-induced organ failure and indicates new paths for successful clinical intervention. Surviving Hypoxia: Mechanisms of Control and Adaptation is an excellent reference for all researchers interested in the physiological effects of hypoxia, underlying pathological events, and protective mechanisms.
TABLE OF CONTENTS
part I|212 pages
Advantageous Biochemical Pathways
section Section A|71 pages
Bioenergetic Advantages
chapter Chapter 3|22 pages
Aerobic and Anaerobic Energy Metabolism in the Life Cycle of Parasitic Helminths
chapter Chapter 4|12 pages
Energy Metabolism of Invertebrate Erythrocytes: Anaerobic Metabolism of Blood Clams
chapter Chapter 5|12 pages
Rice and Wheat Seedlings as Plant Models of High and Low Tolerance to Anoxia
section Section B|61 pages
Efficiency Advantages
chapter Chapter 8|16 pages
Effects of Thyroid Hormone on the Energetic Efficiency of Muscle Contraction
section Section C|76 pages
pH Advantages
chapter Chapter 14|14 pages
pH and Metabolic Depression in Mammalian Hibernation. The Example of Brown Adipose Tissue
part II|134 pages
Hypoxia Defense and Control Systems
chapter Chapter 16|16 pages
The Role of Metabolic Acidosis in the Buffering of ATP by Phosphagen Stores in Fish: An In Vivo NMR Study
chapter Chapter 18|10 pages
Inhibition of Protein Synthesis in Isolated Hepatocytes as an Immediate Response to Oxygen Limitation
part III|65 pages
Membrane-Metabolism Interface
chapter Chapter 25|23 pages
Membrane Current Activation and Inactivation During Hypoxia in Hippocampal Neurons
chapter Chapter 27|13 pages
Neurotransmitters and Anoxia Resistance: Comparative Physiological and Evolutionary Perspectives
part IV|55 pages
Integrated Systems
chapter Chapter 28|18 pages
Hypoxia and Posthypoxic Recovery in Insects: Physiological and Metabolic Aspects
chapter Chapter 29|11 pages
Hypoxia Tolerance in Amazon Fishes: Status of an Under-Explored Biological “Goldmine”
chapter Chapter 31|11 pages
Hypoxia Defense Mechanisms: A Comparison between Diving Reptiles and Mammals
part V|69 pages
Recovery
part VI|9 pages
Summary