ABSTRACT

This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols.

Key Features

  • Presents the first full guide to single-stranded RNA phages
  • Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences
  • Demonstrates how RNA phage-derived products have resulted in nanotechnological applications
  • Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies

chapter 1|27 pages

History and First Look

chapter 2|16 pages

Taxonomy and Grouping

chapter 3|23 pages

Pili and Hosts

chapter 4|30 pages

Physiology and Growth

chapter 5|11 pages

Distribution

chapter 6|56 pages

Ecology

chapter 7|8 pages

Genome

chapter 8|14 pages

Genetics and Mutants

chapter 9|15 pages

Particles

chapter 10|31 pages

RNA

chapter 11|9 pages

Maturation Protein

chapter 12|9 pages

Coat Protein

chapter 13|33 pages

Replicase

chapter 14|9 pages

Lysis Protein

chapter 15|12 pages

Immunology

chapter 16|52 pages

Translation

chapter 17|15 pages

Replication

chapter 18|38 pages

Evolution

chapter 19|15 pages

Expression

chapter 20|32 pages

Chimeric VLPs

chapter 21|22 pages

3D Particles

chapter 22|26 pages

VLP Vaccines

chapter 23|19 pages

Non-Vaccine VLPs

chapter 24|17 pages

Non-VLPs

chapter 25|8 pages

Epilogue