ABSTRACT
Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel.
Key Features:
- Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption
- Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery
- Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption
TABLE OF CONTENTS
chapter 3|12 pages
In Vivo Percutaneous Absorption
A Key Role for Stratum Corneum/Vehicle Partitioning
chapter 5|12 pages
Chemical Partitioning into Powdered Human Stratum Corneum
A Useful In Vitro Model for Studying the Interaction of Chemicals and Human Skin
chapter 8|16 pages
The Correlation between Transepidermal Water Loss and Percutaneous Absorption
An Updated Overview
chapter 11|10 pages
Regional Variation in Percutaneous Absorption
Principles and Applications to Human Risk Assessment
chapter 19|8 pages
Understanding Skin Metabolism–Effect on Altering In Vitro Skin
Absorption and Bioavailability of Topically Applied Chemicals
chapter 25|8 pages
Chemical Warfare Agent VX Penetration through Military Uniform and Human Skin
Risk Assessment and Decontamination
chapter 34|10 pages
Chemical Modification
An Important and Feasible Method for Improving Peptide and Protein Dermal and Transdermal Delivery
chapter 49|10 pages
Effects of Phospholipids on Skin
Use of Primary Human Keratinocytes and Fibroblasts as 2D Cell Culture Models
chapter 50|6 pages
Human Cadaver Skin Viability for In Vitro Percutaneous Absorption
Storage and Detrimental Effects of Heat Separation and Freezing
chapter 54|26 pages
Blood Flow as a Technology in Percutaneous Absorption
The Assessment of the Cutaneous Microcirculation by Laser Doppler and Photoplethysmographic Techniques
chapter 56|32 pages
Microscopy Methods for Assessing Percutaneous Drug Penetration
Percutaneous Absorption-Drugs-Cosmetics-Mechanism-Methodology
chapter 60|10 pages
Bioequivalence, Pharmaceutical Equivalence, and Biowaivers
Topical Dosage Forms for Local Action
chapter 63|10 pages
Percutaneous Penetration in Humans
Transfer of Chemicals via Skin-to-Skin Contact
