ABSTRACT
Published in 1991: Since its characterization in the 1970s from antigen-stimulated rabbit basophils, platelet-activating factor (PAF) has been demonstrated to be produced by, and act upon, a variety of cell types. PAF antagonists, which have been obtained from both natural sources and chemical synthesis, now represent a new class of therapeutic agents and may provide new prospects for treating several major pathologies, particularly shock, ischemia and asthma. This book provides a unique overview of the chemistry, molecular modeling, pharmacology, and clinical potential of the major classes of natural and synthetic PAF antagonists. Compounds reviewed include the ginkgolides, diketopiperazines, neolignans, hetrazepines, cyclic and 1,3-dioxolan derived PAF analogs, pyrrolo[1,2-c]thiazoles, imidazo[2,1-a]isoquinolines and pyridoquinazoline carboxamides. Consisting of 12 chapters written by leading experts in PAF antagonist research, this book is essential reading for students, researchers, clinicians, and medical practitioners involved in this rapidly developing field of biomedical research.
TABLE OF CONTENTS
part I|3 pages
Natural PAF Antagonists
chapter Chapter 2|10 pages
PAF Antagonists from Microbial Origin: Structure-Activity Relationship of Diketopiperazine Derivatives
chapter Chapter 3|14 pages
Kadsurenone Type Neolignans, Potential PAF Antagonists: Chemistry and Distribution
part II|2 pages
Synthetic PAF Antagonists
chapter Chapter 4|22 pages
Structure Activity Relationships in CV-3988 and CV-6209 PAF Antagonists Series
chapter Chapter 7|14 pages
Structure Activity Relationships in Cyclic Analogs of PAF with PAF Antagonist Properties
chapter Chapter 9|18 pages
Structure-Activity Relationships in Pyrrolo[1,2-c]Thiazoles PAF Receptor Antagonists
chapter Chapter 10|8 pages
Structure Activity Relationships in 5-Aryl-2,3-Dihydroimidazo[2,1a]Isoquinoline PAF Antagonists
part III|2 pages
Molecular Modeling