ABSTRACT
First published in 1991. Historically, phospholipid binding antibodies were important in the study of syphilis. During the 1980s there was a resurgence of new interest in these antibodies due to reported associations with recurrent thrombosis, fetal loss, and other clinical disorders. Because of the variety of reported clinical associations and their occurrence in systemic autoimmune disorders, these antibodies have become important in many medical fields, such as clinical immunology, rheumatology, hematology, and obstetrics and gynecology. Phospholipid-Binding Antibodies provides in-depth reviews by specialists in these clinical areas and covers topics including the biochemistry of phospholipids, their role in coagulation, phospholipid immunology, and lupus anticoagulant and antiphospholipid antibodies by solid phase immunoassays. Other topics include thrombosis and fetal loss, as well as the role of phospholipid binding antibodies in these disorders. Antiphospholipid Syndrome and its reported clinical associations is also discussed.
TABLE OF CONTENTS
section Section I|56 pages
Phospholipids and Clotting
section Section II|81 pages
The Immunology of Phospholipid-Binding Autoantibodies
section Section III|49 pages
Measurement of Phospholipid-Binding Antibodies
chapter Chapter 8|18 pages
Lupus Anticoagulants: Characteristics, Methods of Laboratory Detection and Some Clinical Associations
section Section IV|79 pages
Phospholipid-Binding Antibodies and Thrombosis
chapter Chapter 12|13 pages
Spontaneous (Unexplained) Thrombosis: The Inherited Basis for the Thrombohemorrhagic Balance
chapter Chapter 14|15 pages
Anti-Phospholipid Antibodies and Impairment of Prostacyclin Synthesis by the Endothelium
section Section V|101 pages
Phospholipid-Binding Antibodies and Pregnancy Loss
chapter Chapter 19|12 pages
Treatment of Anti-Phospholipid Antibody Mediated Fetal Loss: The Case for Corticosteroid Therapy
chapter Chapter 20|12 pages
Clinical Implications of Anti-Phospholipid Antibodies: The Utah Experience
chapter Chapter 21|8 pages
Alternative Approaches to Treatment of Women with Anti-Phospholipid Antibodies and Fetal Loss
section Section VI|49 pages
The Anti-Phospholipid Syndrome