ABSTRACT
This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.
Key Features
- Provides historical context of the contributions of the model system
- Includes contributions from an international team of leading scholars
- Presents topics spanning cell biology, developmental biology, genomics, and disease model
- Describes recent experimental advances
- Incorporates richly illustrated diagrams and color images
Related Titles
Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)
Faber, J. & P. D. Nieuwkoop. Normal Table of Xenopus laevis (Daudin): A Systematical & Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis (ISBN 978-0-8153-1896-5)
Jarret, R. L. & K. McCluskey. The Biological Resources of Model Organisms (ISBN 978-1-0320-9095-5)
The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
TABLE OF CONTENTS
section Section I|151 pages
Contributions to Cell, Developmental, and Molecular Biology
chapter 8|17 pages
The Development and Evolution of the Vertebrate Neural Crest
chapter 9|9 pages
The Use of Xenopus Oocytes to Study the Biophysics and Pharmacological Properties of Receptors and Channels
section Section II|69 pages
Systems Biology and the Genomic Era
section Section III|113 pages
From Basic Biological Insights to Human Disease