ABSTRACT
Spherical nucleic acids (SNAs) comprise a nanoparticle core, and a densely packed and highly oriented nucleic acid shell. They have novel structure-dependent properties that differ from those of linear nucleic acids and that makes them useful in chemistry, biology, the life sciences, medicine, materials science, and engineering. This book is a reprint volume that compiles 101 key papers that have been published by the Mirkin Group at Northwestern University, USA, and their collaborators over the past more than two decades. Volume 1 provides an overview and a historical framework of SNAs and discusses their enabling features, which set them apart from all other forms of matter. Volume 2 covers the general design rules for colloidal crystal engineering with DNA, spanning the building blocks and DNA- and RNA-based "programmable bonds" that can be utilized in preparing such structures. Volume 3 continues the discussion of colloidal crystallization processes and routes to hierarchical assembly, featuring dynamic nanoparticle superlattices and lattices prepared on surfaces or via templating strategies, and explores what one can uniquely learn from and do with colloidal crystals prepared from nucleic acid–functionalized nanomaterials in optics, plasmonics, and catalysis. Volume 4 covers the role of SNAs in biomedicine, especially as diagnostic probes both inside and outside of cells, and treatments based on gene regulation and immunotherapy.
TABLE OF CONTENTS
part 6|115 pages
Colloidal Crystallization Processes and Routes to Hierarchical Assembly
chapter Chapter 48|20 pages
Assembly and Organization Processes in DNA-Directed Colloidal Crystallization*
part 7|74 pages
Dynamic Nanoparticle Superlattices
chapter Chapter 55|11 pages
Contraction and Expansion of Stimuli-Responsive DNA Bonds in Flexible Colloidal Crystals*
part 8|128 pages
Surface-Based and Template-Confined Colloidal Crystallization
chapter Chapter 61|16 pages
Epitaxial Growth of DNA-Assembled Nanoparticle Superlattices on Patterned Substrates*
chapter Chapter 64|14 pages
Building Superlattices from Individual Nanoparticles via Template-Confined DNA-Mediated Assembly*
chapter Chapter 66|14 pages
DNA-Mediated Size-Selective Nanoparticle Assembly for Multiplexed Surface Encoding*
chapter Chapter 67|14 pages
Conformal, Macroscopic Crystalline Nanoparticle Sheets Assembled with DNA*
part 9|144 pages
Optics and Plasmonics with Nanoparticle Superlattices
chapter Chapter 69|16 pages
Nanoscale Form Dictates Mesoscale Function in Plasmonic DNA-Nanoparticle Superlattices*
chapter Chapter 70|15 pages
Directional Emission from Dye-Functionalized Plasmonic DNA Superlattice Microcavities*
chapter Chapter 71|18 pages
Defect Tolerance and the Effect of Structural Inhomogeneity in Plasmonic DNA-Nanoparticle Superlattices*
chapter Chapter 72|18 pages
Using DNA to Design Plasmonic Metamaterials with Tunable Optical Properties*
chapter Chapter 74|19 pages
Design Principles for Photonic Crystals Based on Plasmonic Nanoparticle Superlattices*
chapter Chapter 75|13 pages
Deterministic Symmetry Breaking of Plasmonic Nanostructures Enabled by DNA-Programmable Assembly*
chapter Chapter 76|14 pages
Polarization-Dependent Optical Response in Anisotropic Nanoparticle-DNA Superlattices*
part 10|30 pages
Postsynthetic Modification and Catalysis with Nanoparticle Superlattices