ABSTRACT
The purpose of this book is to provide information on senescent cells and why they are prevented from multiplying via cell division. It includes main sections on the nature of Go/1 transition, factors promoting the cell cycle traverse and avoiding the Go/1 arrest, and negative factors arresting the cell cycle traverse and promoting the stay in the Go/1 stage. Filled with illustrations and explanations, it collectively presents the mechanisms that control the cellular aging process. This reference is a must for anyone with special interests in the biological community, and specifically the field of gerontology.
TABLE OF CONTENTS
section Section I|2 pages
Introduction
section Section II|118 pages
Positive Control of Cell Proliferation
chapter Chapter 3|10 pages
Changes in Gene Expression During Senescence/Immortalization of Mouse Embryo Fibroblasts
chapter Chapter 4|13 pages
Nuclear Responsiveness to Intracellular Signals in Normal and Senescent Lymphocytes
chapter Chapter 7|32 pages
The Proliferating Cell Nuclear Antigen, PCNA, a Cell Growth-Regulated DNA Replication Factor
section Section III|58 pages
Negative Control of Cell Proliferation
chapter Chapter 9|11 pages
Inhibitors of DNA Synthesis in Senescent and Quiescent Human Diploid Fibroblasts
chapter Chapter 11|16 pages
Programmed Gene Expressions Suggest Multiple Blocks to Replication During Cell Aging
section Section IV|74 pages
General Related Subjects
chapter Chapter 12|10 pages
A Potential Role for Interspersed Repetitive Sequence Elements in Negative Growth Regulation
chapter Chapter 15|17 pages
Cellular Factors Related to Cessation of Proliferation and Differentiation
chapter Chapter 16|14 pages
Control of Muscle Differentiation by Mitogens: A Rationale for Multiple Restriction Points in the Cell Cycle
section Section V|5 pages
Summary
