ABSTRACT

Pharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals.

Features:

  • Discusses specific points of great current relevance in relation to new processes as well as traditional processes
  • Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream
  • Includes chapters that allow a broad evaluation of the production process

Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries.

Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries.

Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.

chapter 1|28 pages

Fundamentals of Biotechnology

chapter 4|17 pages

Molecular Biology

Tools in Industrial Pharmaceutical Biotechnology

chapter 5|16 pages

Molecular Biology Tools

Techniques and Enzymes

chapter 7|17 pages

Bioprocesses

Microorganisms and Culture Media

chapter 10|23 pages

Bioreactors

Modes of Operation

chapter 11|13 pages

Agitation and Aeration

Oxygen Transfer and Cell Respiration

chapter 14|18 pages

Lipopolysaccharides

Methods of Quantification and Removal from Biotechnological Products

chapter 15|7 pages

Enzymes

The Catalytic Proteins