ABSTRACT
The pace and sophistication of advances in medicine in the past two decades have necessitated a growing need for a comprehensive reference that highlights current issues in medicine. Each volume in the Current Issues in Medicine series is a stand‐alone text that provides a broad survey of various critical topics—all accomplished in a user-friendly yet interconnected format. The series not only highlights current advances but also explores related topics such as translational medicine, regulatory science, neglected diseases, global pandemics, patent law, immunotoxicology, theranostics, big data, artificial intelligence, novel imaging tools, combination drug products, and novel therapies. While bridging the gap between basic research and clinical medicine, this series provides a thorough understanding of medicine’s potential to address health problems from both the patient’s and the provider’s perspectives in a healthcare setting. The range of topics covered and the expertise of the contributing authors accurately reflect the rapidly evolving areas within medicine—from basic medical sciences to clinical specialties. Each volume is essential reading for physicians, medical students, nurses, fellows, residents, undergraduate and graduate students, educators, policymakers, and biomedical researchers. The multidisciplinary approach of the series makes it a valuable reference resource for the pharmaceutical industry, academia, and governments. However, unlike other series on medicine or medical textbooks, this series focuses on current trends, perspectives, and issues in medicine that are central to healthcare delivery in the 21st century. Volume 1 focuses on the current issues in basic medical sciences, subjects that are fundamental to the practice of medicine. Specifically, it covers medical biochemistry, genomics, physiology, and pathology. These subjects, traditionally taught in the first two years of medical school that precede clinical instruction, provide a core of basic knowledge critical to the success in clinical medicine during rotations, training, and medical practice.
TABLE OF CONTENTS
part Section 1|428 pages
Medical Biochemistry and Genomics
chapter Chapter 3|20 pages
How Physical and Chemical Information Predicts the Action of Molecules: A Historical Overview
chapter Chapter 4|26 pages
Three-Dimensional Chromatin in Infectious Disease: A Role for Gene Regulation and Pathogenicity?
chapter Chapter 6|24 pages
Identifying Genetic Markers Associated with Susceptibility to Cardiovascular Diseases
chapter Chapter 7|23 pages
Production and Application of Multicistronic Constructs for Various Human Disease Therapies
chapter Chapter 11|24 pages
Advancing Clinical Cohort Selection with Genomics Analysis on a Distributed Platform
chapter Chapter 13|29 pages
Nanocrystals: The Universal Formulation Principle to Improve the Bioactivity of Poorly Soluble Actives
chapter Chapter 17|16 pages
Polygenic Risk-Tailored Screening for Prostate Cancer: A Benefit–Harm and Cost-Effectiveness Modelling Study
chapter Chapter 18|14 pages
Apoptotic Bodies: Particular Extracellular Vesicles Involved in Intercellular Communication
part Section 2|161 pages
Human Physiology and Pathology