ABSTRACT
Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions.
Key Features
- Structure and biosynthesis of mammalian peroxidases
- Reactivity of hypohalous acids with biological substrates
- Peroxidases in innate immunity
- Peroxidases in human pathology
- Modulation of peroxidase-induced biological damage
TABLE OF CONTENTS
part One|50 pages
Introduction to Mammalian Heme Peroxidases
chapter Chapter Two|20 pages
Biosynthesis of Mammalian Heme Proteins, Peroxidases, and NADPH Oxidases
part Two|100 pages
Reactivity of Peroxidase Oxidants
chapter Chapter Four|25 pages
Reactivity of Peroxidase-Derived Oxidants with Proteins, Glycoproteins and Proteoglycans
chapter Chapter Six|20 pages
Reactivity of Peroxidase Oxidants with Lipids: The Generation of Biologically Important Modified Lipids
part Three|53 pages
Peroxidases in Innate Immunity
chapter Chapter Ten|17 pages
Bactericidal Activity of the Oxidants Derived from Mammalian Heme Peroxidases
part Four|100 pages
Peroxidases in Pathology
chapter Chapter Thirteen|9 pages
Role of Myeloperoxidase in Endothelial Dysfunction and Altered Cell Signaling in Atherosclerosis
chapter Chapter Sixteen|12 pages
The Pathogenesis and Consequences of Myeloperoxidase-Dependent ANCA Vasculitis and Glomerulonephritis
part Five|15 pages
Prevention of Myeloperoxidase-Induced Damage