ABSTRACT
In the 1960s, Sydney Brenner proposed to use the nematode worm Caenorhabditis elegans to discover the control mechanisms of animal development and to reveal how a small number of neurons generate different behaviours, giving birth to a vibrant community that uses this animal model for their studies. Brenner was aided in his aim by John Sulston, who mapped the C. elegans cell lineages – from a single cell to the multicellular adult – which transformed the field of developmental biology.
As a tribute to these two men, this book captures the perspectives of some of the early pioneers of the worm community, from Martin Chalfie, Robert Waterston and Donald Moerman to Catherine Rankin, Antony Stretton and John White. It also includes contributions from subsequent generations of the community, who explore the development and function of the C. elegans nervous system. This book features how this animal has become one of the best models for elucidating the biology of different sensory modalities and their complex behavioural outputs, or how this animal’s survival strategies have contributed to our understanding of ageing and neurodegeneration. Thus, this volume documents the development of the C. elegans neuroscience field, from infancy to maturity.
The chapters in this book were originally published as a special issue of the Journal of Neurogenetics.
TABLE OF CONTENTS
part I|36 pages
The early years of C. elegans neurogenetics
part II|90 pages
Nervous system development
part III|44 pages
From inputs to outputs
part IV|40 pages
Social and sexual behaviors
part V|50 pages
Quiescence and sleep
part VI|76 pages
Survival, aging and disease
part VII|14 pages
Worm photo and art gallery