ABSTRACT

Modelling Survival Data in Medical Research, Fourth Edition, describes the analysis of survival data, illustrated using a wide range of examples from biomedical research. Written in a non-technical style, it concentrates on how the techniques are used in practice. Starting with standard methods for summarising survival data, Cox regression and parametric modelling, the book covers many more advanced techniques, including interval-censoring, frailty modelling, competing risks, analysis of multiple events, and dependent censoring.

This new edition contains chapters on Bayesian survival analysis and use of the R software. Earlier chapters have been extensively revised and expanded to add new material on several topics. These include methods for assessing the predictive ability of a model, joint models for longitudinal and survival data, and modern methods for the analysis of interval-censored survival data.

Features:

  • Presents an accessible account of a wide range of statistical methods for analysing survival data
  • Contains practical guidance on modelling survival data from the author’s many years of experience in teaching and consultancy
  • Shows how Bayesian methods can be used to analyse survival data
  • Includes details on how R can be used to carry out all the methods described, with guidance on the interpretation of the resulting output
  • Contains many real data examples and additional data sets that can be used for coursework
  • All data sets used are available in electronic format from the publisher’s website

Modelling Survival Data in Medical Research, Fourth Edition, is an invaluable resource for statisticians in the pharmaceutical industry and biomedical research centres, research scientists and clinicians who are analysing their own data, and students following undergraduate or postgraduate courses in survival analysis.

chapter Chapter 1|14 pages

Survival analysis

chapter Chapter 2|34 pages

Some non-parametric procedures

chapter Chapter 3|66 pages

The Cox regression model

chapter Chapter 4|32 pages

Model checking in the Cox regression model

chapter Chapter 5|70 pages

Parametric regression models

chapter Chapter 6|18 pages

Flexible parametric models

chapter Chapter 7|16 pages

Model checking in parametric models

chapter Chapter 8|34 pages

Time-dependent variables

chapter Chapter 9|16 pages

Interval-censored survival data

chapter Chapter 10|30 pages

Frailty models

chapter Chapter 11|22 pages

Non-proportional hazards and institutional comparisons

chapter Chapter 12|20 pages

Competing risks

chapter Chapter 13|22 pages

Multiple events and event history modelling

chapter Chapter 14|12 pages

Dependent censoring

chapter Chapter 15|12 pages

Sample size requirements for a survival study

chapter Chapter 16|28 pages

Bayesian survival analysis

chapter Chapter 17|48 pages

Survival analysis with R