ABSTRACT
Autophagy and Signaling is an up-to-date overview of the many signaling pathways regulating autophagy in response to different cellular needs. Discussion includes the status and future directions of autophagy signaling research with respect to different aspects of health and disease. These include the roles of autophagy in regulating cell fate, immune response and host defense, nutrient sensing and metabolism, neural functions and homeostasis. The mechanisms and significance of cross-talk between autophagy and other cellular processes is also explored. Lastly, alterations in autophagy observed in aging and age-related pathologies are described.
TABLE OF CONTENTS
section I|40 pages
Signaling Pathways Regulating Autophagy
section II|50 pages
Autophagy and Cell Fate
chapter 3|24 pages
Cross Talk between Autophagy and Cell Death Pathways
section III|82 pages
Autophagy in Immunity and Metabolism
section IV|90 pages
Autophagy in Neural Homeostasis and Neurodegeneration