ABSTRACT
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications.
Key Features
- Outlines therapies and techniques for HSCT for autoimmune diseases
- Discusses the advantages of HSCT over conventional therapies
- Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
TABLE OF CONTENTS
part Section I|57 pages
Biology of Immune Cells
part Section II|44 pages
Biology of Stem Cells
part Section III|20 pages
Regulatory Requirements
chapter 13|7 pages
European Perspective on Cellular Therapy
part Section IV|67 pages
Mesenchymal Stem Cells for Immune Diseases
chapter 17|9 pages
Musculoskeletal Stromal/Progenitor Cell-Based Cell Therapy for Rheumatoid Arthritis (RA)
part Section V|103 pages
General Concepts — HSCT for Autoimmune Diseases
chapter 31|11 pages
International Registries Sites/Indications/Activity for Hsct in Autoimmune Diseases
part Section VI|43 pages
Allogeneic HSCT for Autoimmune Disease
chapter 34|10 pages
Allogeneic HSCT and Graft Versus Host Disease (GvHD)
part Section VII|191 pages
HSCT for Autoimmune Disease
chapter 43|8 pages
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
chapter 46|10 pages
Neuromyelitis Optica
chapter 52|9 pages
Crohn's Disease
chapter 54|9 pages
Type 1 Diabetes Mellitus
chapter 55|8 pages
Systemic Lupus Erythematosus
part Section VIII|73 pages
HSCT for Autoimmune Disease — Developing Indications
chapter 56|8 pages
Refractory Celiac Disease
part Section IX|13 pages
Ethics and Economics