ABSTRACT
Performing a thorough and detailed study of one of the most common yet less accurately understood causes of human illness, this all-inclusive reference examines the epidemiology, pathophysiology, and future treatment options for asthma and respiratory infections.
Contains up-to-date results from clinical trials of antiviral agents that expl
TABLE OF CONTENTS
chapter 2|22 pages
Respiratory Viruses and Asthma: Epidemiological Considerations in Evaluating Their Association
J. WITEK, Jr.
chapter |7 pages
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of both children and adults. of viruses was far more common during exacerbations of infection. Clarke (32) of 51 adult asthmatics, recruited from a hospital outpatient of these exacerbations and RT viruses isolated in 4 of these of 10.8%. A similar identification rate was found by Hudgel of 19 patients from a hospital clinic. Viral identification
chapter |2 pages
of Virus-Induced Asthma
of the replicating virus on the cell and of the host to this infection. This response has both an innate compo-
chapter |2 pages
of Virus-Induced Asthma 93
of the submucosal and adventitial extracellular of fluid exudation from the capillaries has only a small effect of the airway lumen. However, when the smooth muscle contracts,
chapter |2 pages
of Virus-Induced Asthma 99
of children who develop recurrent wheezing and of viral respiratory infection in infancy frequently show al-
chapter 6|26 pages
The Use of Experimentally Infected Volunteers in Research on the Common Cold
I. Introduction
chapter |6 pages
of Experimental Provocation Models
of nasal spray from an atomizer and/or nasal inhala- of these methods have been designed to enhance of these methods has been
chapter |2 pages
of Respiratory Virus Infections 223
of the specimen should be made prior to storage. For antigen of 4°C (or -20°C for longer periods) is often
chapter |2 pages
of Respiratory Virus Infections 225
Detection of Viral Antigen of viruses in nasopharyngeal aspirates of patients with acute respi- of the original rapid diagnostic methods.
chapter |2 pages
of Respiratory Virus Infections 227
of a single chain of nucleotides. Viral nucleic acids are usually double-
chapter |2 pages
of Respiratory Virus Infections 229
"dot" or a "slot" for subsequent probing. This slot-blot of being semi-quantitative if a
chapter |6 pages
of Respiratory Virus Infections
of the PCR assay have been varied according to the application of this theme applicable to the of respiratory viruses are discussed. Nested PCR involves a second of 15-30 cycles of PCR performed on the first-round PCR product using
chapter |2 pages
of Respiratory Virus Infections 237
of PCR method, the target virus genome, and detection limits of
chapter |6 pages
of Respiratory Virus Infections
of a dual infection in 20% by RT-PCR compared of commercial extrac- of the PCR processes, and accessibility to virus
chapter |12 pages
of Therapy
Rhinoviruses of rhinovirus infections has been attempted in many of the virus in 1956. In spite of the effort and