ABSTRACT
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from a renowned course on receptor pharmacology, this text presents in-depth coverage of this rapidly expanding research area. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions.
TABLE OF CONTENTS
part |2 pages
Section I: Drug-Receptor Interactions
part |2 pages
Section II: Molecular Structure of Receptors
part |2 pages
Section III: Ligand-Binding Studies of Receptors
part |2 pages
Section IV: Transduction of the Receptor Signal
part |2 pages
Section V: Receptors as Pharmaceutical Targets