The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev

chapter 2|10 pages

A Brief History of Protein Disorder

chapter 4|12 pages

Hydrodynamic Techniques

chapter 6|12 pages

Nuclear Magnetic Resonance

chapter 8|12 pages

IDPs under Conditions Approaching In Vivo

chapter 9|18 pages

Prediction of Disorder

chapter 10|22 pages

Structure of IDPs

chapter 11|20 pages

Biological Processes Enriched in Disorder

chapter 12|26 pages

Molecular Functions of Disordered Proteins

chapter 13|16 pages

Evolution and Prevalence of Disorder

chapter 14|32 pages

Extension of the Structure-Function Paradigm

chapter 15|28 pages

Structural Disorder and Disease