ABSTRACT
"This valuable resource provides detailed health and safety information on the hazardous and toxic properties of over 1,000 heavily used industrial and consumer chemicals. Lists chemicals both alphabetically and numerically according to their Chemical Abstract Service number permitting rapid access to specific data!"
TABLE OF CONTENTS
chapter I|1 pages
SOURCES OF TOXICITY DATA
The following is a listing of major sources and references the reader can refer to in obtaining additional information on the toxicity of chemicals. DEPARTMENT Of HEALTH AND HUMAN SERVICES (DHHS) Annual Report on Carcinogens Section 301(b)(4) of the Public Health Service Act, as amended In addition, these reports are to provide information on the nature and degree of exposures to such carcinogens, and the extent to which Federal regulations are effective in reducing the risk to the public health from exposures to these substances. II. NATIONAL TOXICOLOGY PROGRAM (NTP)
chapter |1 pages
Compilation of this list is the initial step in OSHA's screening process for suspected carcinogens. To compile this list, substances for which there was some evidence of carcinogenicity and potential occupational hazard were drawn from such lists the NIOSH Registry of Toxic Effects of Chemical Substances (RTECS); U.S. Public Health Service, Publication No. 149; EPA's Inventory of Chemical Substances; the monographs of the International Agency for Research on Cancer; and the Annual Report of the Secretary of the U.S. Department of Health and Human Services to the President and the Congress. The substances which are found in American work places, and for which there some evidence of carcinogenicity, are subjected to a brief scientific review of available literature to determine whether or not a substance should be subject to a more thorough review under the OSHA Cancer Policy. Based on the more detailed review, a determination may then be made to whether a substance meets OSHA's definition of a potential occupational carcinogen. Substances Regulated by the Occupational Safety and Health Administration (OSHA) on the Basis of Carcinogenicity Since 1970, OSHA has promulgated rules regulating 18 chemicals on the basis of carcinogenicity. V. NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH (NIOSH) A. Criteria Document for a Recommended Standard The National Institute for Occupational Safety and Health (NIOSH) ••• develops and periodically revises Criteria Documents that
recommend standards for occupational exposure to chemical and physical hazards. The NIOSH critically evaluates all known and available medical, biological, engineering, chemical, and trade data and informa- tion that may be relevant to recommending a standard in the criteria document.
chapter |1 pages
of an occupational health Standard." or are of a "Current Intelligence Bulletin." or teratogenic of Chemicals Having Substantial Evidence of of the of Pesticides and Toxic Substances to develop labeling regulations of the Resource Conservation and Recovery Act. of information used in selecting chemicals as candidates for the
B. Current Intelligence Bulletins In January 1975, the National Institute for Occupational Safety and Health (NIOSH) developed a Current Intelligence Bulletin System to " ... promptly review, evaluate, and supplement new information reviewed NIOSH on occupational hazards that are either unrecognized
chapter |1 pages
to other agencies, and decisions to list the chemical for a Section 8 reporting rule or to undertake a formal risk assessment. D. Toxic Substances Control Act: Premanufacture Notification (PMN) Under Section 5(a)(l) of the Toxic Substances Control Act of 1976 (TSCA) anyone who intends to introduce into commerce a chemical substance not on the 1977 TSCA Inventory must notify the EPA at least 90 days before beginning manufacture or importation. The EPA is to use the review period to determine if the substance might present an unreasonable risk. Upon such determination, the EPA may issue an order to prohibit manufacture and may then apply to the court for an injunction to this effect. In the absence of such an order or immediate rule, the manufacturer may proceed with the plans to introduce the substance. The EPA publishes in the Federal Register a summary of each PMN five days after its receipt. E. List of Hazardous Constituents, Appendix VIII of the Resource Conservation and Recovery Act of 1976 Subtitle C of the Solid Waste Disposal Act, amended by the Resource Conservation and Recovery Act of 1976 (RCRA), directs the EPA to promulgate regulations to protect human health and the environ-ment from the improper management of hazardous wastes. Part 261 of this Act defines a hazardous waste to be a substance or mixture which may " been shown in reputable scientific studies compiled by the EPA, to have toxic, carcinogenic, mutagenic, or teratogenic effects on humans or other life forms. The Appendix used by the Agency to identify those toxic constituents which, if present in a waste, could result in the waste being placed on the hazardous waste list. Appendix VIII presently contains 330 chemical substances and 29 classes of chemical substances. The EPA expects to add other
cause, or significantly contribute to, an increase in mortality or an increase in serious irreversible or incapacitating reversible illness, or pose a substantial present or potential hazard to human health or the environment when it improperly treated, stored, transported, disposed of or otherwise managed . . . " Appendix VIII of Part 261 is a list of toxic chemicals that have
chapter |5 pages
mE mE
mAT OF 98-50-0 ARSANILIC ACID mERE IS INADEQUATE EVIDENCE FOR mERE SUFFICIENT EVI- mAT INORGANIC ARSENIC COMPOUNDS ARE SKIN AND mE mAT
chapter |1 pages
*** TRP-P-1(3-AMIN0-1,4-DIMETHYL-5H-PYRID0-
62450-06-0 (4,3-B)INDOLE) AND ITS ACETATE