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      Handbook of Analysis of Oligonucleotides and Related Products
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      Book

      Handbook of Analysis of Oligonucleotides and Related Products

      DOI link for Handbook of Analysis of Oligonucleotides and Related Products

      Handbook of Analysis of Oligonucleotides and Related Products book

      Handbook of Analysis of Oligonucleotides and Related Products

      DOI link for Handbook of Analysis of Oligonucleotides and Related Products

      Handbook of Analysis of Oligonucleotides and Related Products book

      Edited ByJose V. Bonilla, G. Susan Srivatsa
      Edition 1st Edition
      First Published 2011
      eBook Published 11 December 2013
      Pub. Location Boca Raton
      Imprint CRC Press
      DOI https://doi.org/10.1201/b10714
      Pages 511
      eBook ISBN 9780429136665
      Subjects Bioscience, Physical Sciences
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      Get Citation

      Bonilla, J.V., & Srivatsa, G.S. (Eds.). (2011). Handbook of Analysis of Oligonucleotides and Related Products (1st ed.). CRC Press. https://doi.org/10.1201/b10714

      ABSTRACT

      Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essen

      TABLE OF CONTENTS

      chapter 1|46 pages

      Purity Analysis and Impurities Determination by Reversed-Phase High- Performance Liquid Chromatography

      chapter 2|58 pages

      Purity Analysis and Impurities Determination by AEX-HPLC

      chapter 3|32 pages

      Purity Analysis and Molecular Weight Determination by Size Exclusion HPLC

      chapter 4|30 pages

      Analysis of Oligonucleotides by Liquid Chromatography and Mass Spectrometry

      chapter 5|52 pages

      Sequence Determination and Con‰rmation by MS/ MS and MALDI-TOF

      chapter 6|24 pages

      Tm Analysis of Oligonucleotides

      chapter 7|22 pages

      Purity and Content Analysis of Oligonucleotides by Capillary Gel Electrophoresis

      chapter 8|20 pages

      Bioanalysis of Therapeutic Oligonucleotides Using Hybridization-Based Immunoassay Techniques

      chapter 9|22 pages

      Oligonucleotide Assay and Potency

      chapter 10|24 pages

      Microbial Analysis: Endotoxin Testing

      chapter 11|20 pages

      Analysis of Residual Solvents by Head Space Gas Chromatography

      chapter 12|10 pages

      Determination of Extinction Coef‰cient

      chapter 13|24 pages

      Structural Determination by NMR

      chapter 14|18 pages

      Infrared Analysis of Oligonucleotides

      chapter 15|22 pages

      Stability Indicating Methods for Oligonucleotide Products

      chapter 16|14 pages

      Analysis by Hydrophilic Interaction Chromatography

      chapter 17|14 pages

      Determination of Base Composition

      chapter 18|12 pages

      Analysis of Metals in Oligonucleotides

      chapter 19|22 pages

      Regulatory Considerations for the Development of Oligonucleotide Therapeutics

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