Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the

chapter 1|22 pages

- Introduction

chapter 2|30 pages

- Classical Design

chapter 5|20 pages

- Method with Inverse-Normal p-values

chapter 8|26 pages

- K-Stage Adaptive Designs

chapter 10|18 pages

- Recursive Adaptive Design

chapter 11|26 pages

- Unblinded Sample-Size Reestimation Design

chapter 13|16 pages

- Adaptive Design with Coprimary Endpoints

chapter 14|24 pages

- Multiple-Endpoint Adaptive Design

chapter 15|12 pages

- Pick-the-Winners Design

chapter 16|32 pages

- The Add-Arm Design for Unimodal Response

chapter 17|20 pages

- Biomarker-Enrichment Design

chapter 18|18 pages

- Biomarker-Informed Adaptive Design

chapter 20|18 pages

- Response-Adaptive Allocation Design

chapter 22|18 pages

- Adaptive Dose-Escalation Trial

chapter 24|22 pages

- Bayesian Approach to Biosimilarity Trial

chapter 25|26 pages

- Adaptive Multiregional Trial Design

chapter 27|18 pages

- Data Analysis of Adaptive Trial

chapter 29|20 pages

- Debates in Adaptive Designs