ABSTRACT
There has been an exponential increase in the volume and quality of published research relating to breast disease over the past decades. This book identifies the 50 key scientific articles in the field of breast disease and breast surgery and examines their importance and impact on current clinical care.
Among thousands of articles, a small fraction are truly 'game changing'. Such studies form the foundations of breast surgery today, and the selection of papers within this book provide the 50 landmark papers every 21st-century breast surgeon needs to know. A commentary to each carefully selected paper explains why these papers are so important, thus providing every surgeon with the foundation stones of knowledge in this fast-moving area.
A valuable reference not only to the established surgeon, but also to breast surgery residents and trainees, as well as to more experienced surgeons as they continue to learn new techniques and approaches and to improve their knowledge of breast disease and treatments. The papers provide an evidence-based resource for those surgeons preparing for professional exams and may inspire clinicians to produce new research.
TABLE OF CONTENTS
part Section One|12 pages
• Epidemiology
chapter Chapter 1|6 pages
Type and Timing of Menopausal Hormone Therapy and Breast Cancer Risk: Individual Participant Meta-Analysis of the Worldwide Epidemiological Evidence
chapter Chapter 2|6 pages
Moderate Alcohol Intake and Cancer Incidence in Women
part Section Two|18 pages
• Screening and Prevention
chapter Chapter 3|6 pages
Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study (NSABP P-1)
chapter Chapter 4|6 pages
The Swedish Two-County Trial of Mammographic Screening for Breast Cancer: Recent Results and Calculation of Benefit
chapter Chapter 5|6 pages
The Benefits and Harms of Breast Cancer Screening: An Independent Review
part Section Three|20 pages
• Diagnostic Imaging
chapter Chapter 6|8 pages
Diagnostic Performance of Digital versus Film Mammography for Breast-Cancer Screening
chapter Chapter 7|6 pages
Screening with Magnetic Resonance Imaging and Mammography of a UK Population at High Familial Risk of Breast Cancer: A Prospective Multicentre Cohort Study (MARIBS)
chapter Chapter 8|6 pages
Comparative Effectiveness of MRI in Breast Cancer (COMICE) Trial: A Randomised Controlled Trial
part Section Four|16 pages
• Surgery: Mastectomy versus Conservation
chapter Chapter 9|6 pages
Twenty-Year Follow-Up of a Randomized Trial Comparing Total Mastectomy, Lumpectomy, and Lumpectomy plus Irradiation for the Treatment of Invasive Breast Cancer
chapter Chapter 10|4 pages
The Association of Surgical Margins and Local Recurrence in Women with Early-Stage Invasive Breast Cancer Treated with Breast-Conserving Therapy: A Meta-Analysis
chapter Chapter 11|6 pages
Ten Year Survival after Breast-Conserving Surgery plus Radiotherapy Compared with Mastectomy in Early Breast Cancer in the Netherlands: A Population-Based Study
part Section Five|20 pages
• De-Escalation of Axillary Surgery
chapter Chapter 12|6 pages
Twenty-Five-Year Follow-Up of a Randomized Trial Comparing Radical Mastectomy, Total Mastectomy, and Total Mastectomy followed by Irradiation
chapter Chapter 13|4 pages
Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival among Women with Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial
chapter Chapter 14|4 pages
Radiotherapy or Surgery of the Axilla after a Positive Sentinel Node in Breast Cancer (EORTC 10981-22023 AMAROS): A Randomised, Multicentre, Open-Label, Phase 3 Non-Inferiority Trial
chapter Chapter 15|6 pages
Sentinel Lymph Node Surgery after Neoadjuvant Chemotherapy in Patients with Node-Positive Breast Cancer: The ACOSOG Z1071 (Alliance) Clinical Trial
part Section Six|20 pages
• Oncoplastic Breast Surgery/Breast Reconstruction
chapter Chapter 16|4 pages
Planning and Use of Therapeutic Mammaplasty: The Nottingham Approach
chapter Chapter 17|4 pages
Oncoplastic Breast-Conserving Surgery for Women with Primary Breast Cancer
chapter Chapter 18|6 pages
Short-Term Safety Outcomes of Mastectomy and Immediate Implant-Based Breast Reconstruction with and without Mesh (iBRA): A Multicentre, Prospective Cohort Study
chapter Chapter 19|6 pages
Improving Breast Cancer Surgery: A Classification and Quadrant per Quadrant Atlas for Oncoplastic Surgery
part Section Seven|28 pages
• Breast Cancer Genomics and Prognostic Tools
chapter Chapter 20|4 pages
Gene Expression Patterns of Breast Carcinomas Distinguish Tumor Subclasses with Clinical Implications
chapter Chapter 21|6 pages
Comprehensive Molecular Portraits of Human Breast Tumours
chapter Chapter 22|6 pages
70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer
chapter Chapter 23|6 pages
21-Gene Assay to Inform Chemotherapy Benefit in Node-Positive Breast Cancer (RxPonder)
chapter Chapter 24|6 pages
PREDICT: A New UK Prognostic Model That Predicts Survival Following Surgery for Invasive Breast Cancer
part Section Eight|24 pages
• Ductal Carcinoma In Situ
chapter Chapter 25|6 pages
Genomic Analysis Defines Clonal Relationships of Ductal Carcinoma In Situ and Recurrent Invasive Breast Cancer
chapter Chapter 26|6 pages
Pathological Features of 11,337 Patients with Primary Ductal Carcinoma In Situ (DCIS) and Subsequent Events: Results from the UK Sloane Project
chapter Chapter 27|6 pages
Effect of Tamoxifen and Radiotherapy in Women with Locally Excised Ductal Carcinoma In Situ: Long-Term Results from the UK/ANZ DCIS Trial
chapter Chapter 28|6 pages
A Prognostic Index for Ductal Carcinoma In Situ of the Breast
part Section Nine|12 pages
• Adjuvant Chemotherapy
chapter Chapter 29|6 pages
Comparisons between Different Polychemotherapy Regimens for Early Breast Cancer: Meta-Analyses of Long-Term Outcome among 100,000 Women in 123 Randomised Trials
chapter Chapter 30|6 pages
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy: CREATE-X
part Section Ten|22 pages
• Adjuvant Endocrine Therapy
chapter Chapter 31|6 pages
Relevance of Breast Cancer Hormone Receptors and Other Factors to the Efficacy of Adjuvant Tamoxifen: Patient-Level Meta-Analysis of Randomised Trials
chapter Chapter 32|6 pages
Long-Term Effects of Continuing Adjuvant Tamoxifen to 10 Years versus Stopping at 5 Years after Diagnosis of Oestrogen Receptor–Positive Breast Cancer: ATLAS, a Randomised Trial
chapter Chapter 33|4 pages
Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer
chapter Chapter 34|6 pages
Anastrozole Alone or in Combination with Tamoxifen versus Tamoxifen Alone for Adjuvant Treatment of Postmenopausal Women with Early Breast Cancer: First Results of the ATAC Randomised Trial
part Section Eleven|24 pages
• Immunotherapy/Systemic Therapy
chapter Chapter 35|6 pages
11 Years' Follow-Up of Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Early Breast Cancer: Final Analysis of the HERceptin Adjuvant (HERA) Trial
chapter Chapter 36|6 pages
Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer
chapter Chapter 37|6 pages
Pembrolizumab for Early Triple-Negative Breast Cancer
chapter Chapter 38|6 pages
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer
part Section Twelve|20 pages
• Adjuvant Radiotherapy
chapter Chapter 39|4 pages
Breast-Conserving Surgery with or without Irradiation in Early Breast Cancer (PRIME II)
chapter Chapter 40|4 pages
Effect of Radiotherapy after Breast-Conserving Surgery on 10-Year Recurrence and 15-Year Breast Cancer Death: Meta-Analysis of Individual Patient Data for 10,801 Women in 17 Randomised Trials
chapter Chapter 41|4 pages
Whole-Breast Irradiation with or without a Boost for Patients Treated with Breast-Conserving Surgery for Early Breast Cancer: 20-Year Follow-Up of a Randomised Phase 3 Trial
chapter Chapter 42|4 pages
Effect of Radiotherapy after Mastectomy and Axillary Surgery on 10-Year Recurrence and 20-Year Breast Cancer Mortality: Meta-Analysis of Individual Patient Data for 8135 Women in 22 Randomised Trials
chapter Chapter 43|4 pages
Hypofractionated Breast Radiotherapy for 1 Week versus 3 Weeks (FAST-Forward): 5-Year Efficacy and Late Normal Tissue Effects; Results from a Multicentre, Non-Inferiority, Randomised, Phase 3 Trial
part Section Thirteen|12 pages
• Bisphosphonates
chapter Chapter 44|6 pages
Adjuvant Zoledronic Acid in Patients with Early Breast Cancer: Final Efficacy Analysis of the AZURE (BIG 01/04) Randomised Open-Label Phase 3 Trial
chapter Chapter 45|6 pages
Long-Term Effects of Anastrozole on Bone Mineral Density: 7-Year Results from the ATAC Trial
part Section Fourteen|6 pages
• Surgery for Metastatic Disease
chapter Chapter 46|6 pages
Locoregional Treatment versus No Treatment of the Primary Tumour in Metastatic Breast Cancer: An Open-Label Randomised Controlled Trial
part Section Fifteen|26 pages
• Breast Cancer in Pregnancy/Prophylactic Surgery for Family History