ABSTRACT

This book describes a unique combination of research programs based on a striking variety of hypotheses and procedures directed toward understanding the sources and consequences of neurobehavioral plasticity. This remarkable attribute of the nervous system -- to be pliable and capable of being shaped or formed by natural or artificial sources toward adaptation or maladaptation -- is considered in terms of the neurochemical forces and neuroanatomical structure that has been found to be pivotal for this function. The impetus for this volume was a symposium held to honor Robert L. Isaacson for his scientific and pedagogical achievements as well as his contributions to behavioral neuroscience.

Corresponding to his three major research interests, the book is divided into three sections as follows:
* the first explores the relationship between the limbic system and behavior, with an emphasis on learning and memory;
* the second considers -- through a wide range of approaches -- issues of plasticity in behavior and brain; and
* the third deals with neural and chemical determinants of normal and abnormal behavior.

This volume is not only a fitting tribute to Isaacson, but also an unusual collection of new evidence, procedures, and theories destined to have significant influence on behavioral neuroscience.

chapter 1|12 pages

Yerkes Primate Research Center

A Historical Perspective

part 1|133 pages

Limbic System and Behavior

chapter 2|18 pages

The Hippocampus and Complex, Nonspatial Discrimination

Is Learning Still “Not Possible”?

chapter 6|18 pages

Septal Regulation of the Hippocampal-Entorhinal Network

Memory Formation and Failure

chapter 8|23 pages

The Septohippocampal Connection

Some Behavioral and Anatomical Relationships

part 2|134 pages

Plasticity in Behavior and Brain

chapter 10|19 pages

Structure and Plasticity of the Hebbian Synapse

The Cascading Events for Memory Storage

chapter 13|12 pages

Hebbian Plasticity in the Hippocampus

Involvement of Protein Phosphorylation and Protein Kinase C

part 3|29 pages

Neural and Chemical Determinants of Normal and Abnormal Behavior

chapter 21|23 pages

The Enigma of Reinforcement

chapter 22|18 pages

Wandering in Alzheimer's Disease

Clinical and Neurobiological Perspectives