ABSTRACT

First published in 2002. Routledge is an imprint of Taylor & Francis, an informa company.

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News and Views

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SUBJECTS AND METHODS

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MATERIALS AND METHODS

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This M onth's Special Section

Mental Illness in the Biological and Adoptive Families of Adopted Schizophrenics twins of the same sex (2). It was for these
ByAdoption has been used as a means of sepa­

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SUBJECTS AND METHODS

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PATIENTS, MATERIALS,

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SUBJECTS AND METHODS

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PATIENTS AND METHODS

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SUBJECTS AND METHODS

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METHODS

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Oriaha! Articles

A Double-blind Comparison With Chlorpromazine

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Clinical and Theoretical implications of 5-HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia

Shitij Kapur, M.D., Ph.D., F.R.C.P.C., Robert B. Zipursky, M.D., F.R.C.P.C., and Gary Remington, M.D., Ph.D., F.R.C.P.C.

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Acknowledgments Bromet, E.J., and Fennig, S. “Epidemiology and Natural History of Schizophrenia.” Biol Psychiatry 46 (1999): 871-881. Reprinted with the permission of Elsevier Science. Heaton, R.K., Gladsjo, J. A., Palmer, B.W., Kuck, J., Marcotte, T.D., and Jeste, D.V. “Stability and Course of Neuropsychological Deficits in Schizophrenia.” Arch Gen Psychiatry 58 (2001): 24-32. Reprinted with the permission of American Medical Association. Robinson, D., Woerner, M.G., Alvir, J.M., Bilder, R., Goldman, R., Geisler, S., Koreen, A., Sheitman, B., Chakos, M., Mayerhoff, D., and Lieberman, J. A. “Predictors of Relapse following Response from a First Episode of Schizophrenia or Schizoaffective Disorder.” Arch Gen Psychiatry 56 (1999): 241-247. Reprinted with the permission of American Medical Association. Akil, M., Pierri, J.N., Whitehead, R.E., Edgar, C.L., Mohila, C., Sampson, A.R., and Lewis, D. A. “Lamina-Specific Alterations in the Dopamine Innervation of the Prefrontal Cortex in Schizophrenic Subjects.” AmJ Psychiatry 156 (1999): 1580-1589. Copyright 1999, the American Psychiatric Association. Reprinted by permission. Arnold, S.E., Trojanowski, J.Q., Gur, R.E., Blackwell, P., Han, L.Y., and Choi, C. “Absence of Neurodegeneration and Neural Injury in the Cerebral Cortex in a Sample of Elderly Patients with Schizophrenia.” Arch Gen Psychiatry 55 (1998): 225-232. Reprinted with the permission of American Medical Association. Barch, D.M., Carter, C.S., Braver, T.S., et al. “Selective Deficits in Prefrontal Cortex Function in Medication-Naive Patients with Schizophrenia.*'Arch Gen Psychiatry 58 (2001): 280-288. Reprinted with the permission of American Medical Association. Gilbert, A.R., Rosenberg, D.R., Harenski, K., Spencer, S., Sweeney, J.A., and Keshavan, M.S. “Thalamic Volumes in Patients with First-Episode Schizophrenia.” AmJ Psychiatry 158 (2001): 618-624. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Glantz, L.A., and Lewis, D.A. “Decreased Dendritic Spine Density on Prefrontal Cortical Pyramidal Neurons in Schizophrenia.” Arch Gen Psychiatry 57 (2000): 65-73. Reprinted with the permission of American Medical Association. Goff, D.C., and Coyle, J.T. “The Emerging Role of Glutamate in the Pathophysiology and Treatment of Schizophrenia.” AmJ Psychiatry 158 (2001): 1367-1377. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Goldstein, J.M., Goodman, J.M., Seidman, L.J., et al. “Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging.” Arch Gen Psychiatry 56 (1999): 537-547. Reprinted with the permission of

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Acknowledgments 331 Laruelle, M., Abi-Dargham, A., van Dyck, C.H., Gil, R., D ’Souza, C.D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S.S., Baldwin, R.M., Seibyl, J.P., Krystal, J.H., Charney, D.S., andlnnis, R.B. “Single Photon Emission Computerized Tomography Imaging of Amphetamine-Induced Dopamine Release in Drug-Free Schizophrenic Subjects.” Proc Natl Acad Sci U.S.A. 93 (1996): 9235-9240. Lim, K.O., Hedehus, M., Moseley, M., et al. “Compromised White Matter Tract Integrity in Schizophrenia Inferred from Diffusion Tensor Imaging.” Arch Gen Psychiatry 56 (1999): 367-374. Reprinted with the permission of American Medical Association. Okubo, Y., Suhara, T., Suzuki, K., Kobayashi, K., Inoue, O., Terasaki, O., Someya, Y., Sassa, T., Sudo, Y., Matsushima, E., Iyo, M., Tateno, Y., and Toru, M. “Decreased Prefrontal Dopamine DI Receptors in Schizophrenia Revealed by PET.” Nature 385 (1997): 634-636. Reprinted by permission from Nature Vol. 385 pp. 634-636. Copyright ® 1997 Macmillan Magazines Ltd. Rajkowska, G., Selemon, L.D., and Goldman-Rakic, P.S. “Neuronal and Glial Somal Size in the Prefrontal Cortex: A Postmortem Morphometric Study of Schizophrenia and Huntington Disease.” Arch Gen Psychiatry 55 (1998): 215-224. Reprinted with the permission of American Medical Association. Selemon, L.D., and Goldman-Rakic, P.S. “The Reduced Neuropil Hypothesis: A Circuit Based Model of Schizophrenia.” Biol Psychiatry 45 (1999): 17-25. Reprinted with the permission of Elsevier Science. Copyright 1999 by the Society of Biological Psychiatry. Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.F., and Weinberger, D.R. “Anatomical Abnormalities in the Brains of Monozygotic Twins Discordant for Schizophrenia.” N Engl J Med 322 (1990): 789-794. Copyright ® 1990 Massachusetts Medical Society. All rights reserved. Bustillo, J.R., Lauriello, J., Horan, W.P., and Keith, S.J. “The Psychosocial Treatment of Schizophrenia: An Update.” AmJ Psychiatry 158 (2001): 163-175. Copyright 2001, the American Psychiatric Association. Reprinted by permission. Castner, S. A., Williams, G.V., and Goldman-Rakic, P.S. “Reversal of Antipsychotic Induced Working Memory Deficits by Short-Term Dopamine DI Receptor Stimulation.” Science 287 (2000): 2020-2022. Reprinted with permission from Science 287 (2000): 2020-2022. Copyright (2000) American Association for the Advancement of Science. Kane, J., Honigfeld, G., Singer, J., and Meltzer, H. “Clozapine for the Treatment Resistant Schizophrenic: A Double-Blind Comparison with Chlorpromazine.” Arch Gen Psychiatry 45, 9 (1988): 789-796. Reprinted with the permission of American Medical Association.

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Acknowledgments Kapur, S., Zipursky, R.B., and Remington, G. “Clinical and Theoretical Implications of 5 HT2 and D2 Receptor Occupancy of Clozapine, Risperidone, and Olanzapine in Schizophrenia.” AmJ Psychiatry 156 (1999): 286-293. Copyright 1999, the American Psychiatric Association. Reprinted by permission. Lidow, M.S., Song, Z.-M., Castner, S.A., Allen, P.B., Greengard, P., and Goldman-Rakic, P.S. “Antipsychotic Treatment Induces Alterations inDendrite-and Spine-Associated Proteins in Dopamine-Rich Areas of the Primate Cerebral Cortex.” Biol Psychiatry 49 (2001): 1-12. Reprinted with the permission of Elsevier Science. Copyright 2001 by the Society of Biological Psychiatry. Meltzer, H.Y., Rabinowitz, J., Lee, M.A., et al. “Age at Onset and Gender of Schizophrenic Patients in Relation to Neuroleptic Resistance.” AmJ Psychiatry 154 (1997): 475-482. Copyright 1997, the American Psychiatric Association. Reprinted by permission.

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