This book focuses on the amphibian, Xenopus, one of the most commonly used model animals in the biological sciences. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to our knowledge in cell biology, developmental biology, molecular biology, and neurobiology. In recent years, with the completion of the genome sequence of the main two species and the application of genome editing techniques, Xenopus has emerged as a powerful system to study fundamental disease mechanisms and test treatment possibilities. Xenopus has proven an essential vertebrate model system for understanding fundamental cell and developmental biological mechanisms, for applying fundamental knowledge to pathological processes, for deciphering the function of human disease genes, and for understanding genome evolution.

Key Features

  • Provides historical context of the contributions of the model system
  • Includes contributions from an international team of leading scholars
  • Presents topics spanning cell biology, developmental biology, genomics, and disease model
  • Describes recent experimental advances
  • Incorporates richly illustrated diagrams and color images

Related Titles

Green, S. L. The Laboratory Xenopus sp. (ISBN 978-1-4200-9109-0)

Faber, J. & P. D. Nieuwkoop. Normal Table of Xenopus laevis (Daudin): A Systematical & Chronological Survey of the Development from the Fertilized Egg till the End of Metamorphosis (ISBN 978-0-8153-1896-5)

Jarret, R. L. & K. McCluskey. The Biological Resources of Model Organisms (ISBN 978-1-0320-9095-5)

The Open Access version of this book, available at www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.

section Section I|151 pages

Contributions to Cell, Developmental, and Molecular Biology

chapter 1|10 pages

A Quick History of Xenopus

“The Humble Batrachian”
ByJohn B. Wallingford
Size: 3.94 MB

chapter 2|12 pages

The Study of Cell Division Control and DNA Replication in Xenopus Egg Extracts

ByAllison M. Jevitt, Susannah Rankin
Size: 0.28 MB

chapter 3|18 pages

Maternal mRNAs and the Making of Cell Lineages in the Early Xenopus Embryo

ByDouglas W. Houston
Size: 0.96 MB

chapter 4|8 pages

Signaling Components in Dorsal-Ventral Patterning and the Organizer in Xenopus

ByEdward M. De Robertis, Nydia Tejeda-Muñoz
Size: 2.16 MB

chapter 5|14 pages

Signaling Pathways in Anterior-Posterior Patterning

ByChenbei Chang
Size: 0.45 MB

chapter 6|12 pages

Wnt Signaling in Tissue Differentiation and Morphogenesis

ByStefan Hoppler, Michael Kühl
Size: 0.80 MB

chapter 7|48 pages

Multiple Functions of Notch Signaling during Early Embryogenesis

BySilvia L. López
Size: 1.68 MB

chapter 8|17 pages

The Development and Evolution of the Vertebrate Neural Crest

Insights from Xenopus
ByJoshua R. York, Carole LaBonne
Size: 1.25 MB

chapter 9|9 pages

The Use of Xenopus Oocytes to Study the Biophysics and Pharmacological Properties of Receptors and Channels

ByAtaúlfo Martínez-Torres, Elizabeth Pereida-Jaramillo
Size: 0.23 MB

section Section II|69 pages

Systems Biology and the Genomic Era

chapter 10|17 pages

The Continuing Evolution of the Xenopus Genome

ByMariko Kondo, Masanori Taira
Size: 2.91 MB

chapter 11|12 pages

Dynamics of Chromatin Remodeling during Embryonic Development

ByGert Jan C. Veenstra
Size: 2.26 MB

chapter 12|11 pages

Gene Regulatory Networks Controlling Xenopus Embryogenesis

ByKen W.Y. Cho, Ira L. Blitz
Size: 2.54 MB

chapter 13|10 pages

The Development of High-Resolution Proteomic Analyses in Xenopus

ByElizabeth Van Itallie, Leonid Peshkin
Size: 0.44 MB

chapter 14|15 pages

Advances in Genome Editing Tools

ByMarko E. Horb, Anita Abu-Daya, Marcin Wlizla, Anna Noble, Matt Guille
Size: 1.36 MB

section Section III|113 pages

From Basic Biological Insights to Human Disease

chapter 15|8 pages

Formation of the Left-Right Axis; Insights from the Xenopus Model

ByAxel Schweickert, Tim Ott
Size: 2.46 MB

chapter 16|12 pages

Discovering the Function of Congenital Heart Disease Genes

ByDelfina Pearledith González, Mustafa K. Khokha
Size: 0.33 MB

chapter 17|13 pages

Craniofacial Development and Disorders—Contributions of Xenopus

ByAshwin Lokapally, Hazel Sive
Size: 1.08 MB

chapter 18|17 pages

Modeling Digestive and Respiratory System Development and Disease in Xenopus

ByScott A. Rankin, Aaron M. Zorn
Size: 4.68 MB

chapter 19|12 pages

Functional Neurobiology in Xenopus Provides Insights into Health and Disease

ByClayton Gordy, Michael Forsthofer, Parthena Soupiadou, Suzan Özugur, Hans Straka
Size: 0.97 MB

chapter 20|11 pages

Leaping toward Understanding of Spinal Cord Regeneration

ByPaula G Slater, Gabriela Edwards-Faret, Juan Larraín
Size: 1.95 MB

chapter 21|11 pages

Studying Tumor Formation and Regulation in Xenopus

ByDieter Tulkens, Kris Vleminckx
Size: 0.84 MB

chapter 22|12 pages

Xenopus: A Model to Study Natural Genetic Variation and Its Disease Implications

ByAvi Leibovich, Sally A. Moody, Steven L. Klein, Abraham Fainsod
Size: 1.36 MB

chapter 23|11 pages

Using Xenopus to Understand Pluripotency and to Reprogram Cells for Therapeutic Use

ByMeghana S. Oak, Eva Hörmanseder
Size: 1.69 MB