Drug-Acceptor Interactions: Modeling theoretical tools to test and evaluate experimental equilibrium effects suggests novel theoretical tools to test and evaluate drug interactions seen with combinatorial drug therapy. The book provides an in-depth, yet controversial, exploration of existing tools for analysis of dose-response studies at equilibrium or steady state. The book is recommended reading for post-graduate students and researchers engaged in the study of systems biology, networks, and the pharmacodynamics of natural or industrial drugs, as well as for medical clinicians interested in drug application and combinatorial drug therapy. Even people without mathematical skills will be able to follow the pros and cons of reaction schemes and their related distribution equations. Chapter 9 is a hands-on guide for software to plot, fit and analyze one’s own data.

chapter 1|1 pages

1A prelude

Size: 0.12 MB

chapter I|3 pages

4 Equilibrium and its formulation

Size: 0.25 MB

chapter 1|28 pages

Simple agonism

Size: 1.77 MB

chapter 2|28 pages

Simple ant-agonism — simple intervention

Size: 1.25 MB
Size: 1.49 MB

chapter II|1 pages

1 Two-state models?

Size: 0.12 MB

chapter II|1 pages

3 Intervention and modulation

Size: 0.09 MB

chapter 5|30 pages

Complex agonism

Size: 0.86 MB

chapter 7|44 pages

Cubic reaction schemes. ATSM and HOTSM

Size: 4.12 MB

chapter III|1 pages

1 Limitations of transformed plots

Size: 0.13 MB

chapter III|1 pages

3 Stepping on the chips

Size: 0.09 MB

chapter III|2 pages

7 Contents of part III

Size: 0.18 MB

chapter 8|20 pages

Choosing and formulating relevant schemes

Size: 0.74 MB

chapter 9|24 pages

Plots, fits and data interpretation

Size: 3.87 MB

chapter 10|26 pages

Hill in hell

Size: 0.78 MB

chapter 11|16 pages

The Schild against other theories

Size: 0.71 MB

chapter 12|30 pages

Ties between synergy and two-state models

Size: 2.83 MB

chapter IV|2 pages

1 Flicks and forces at a nano-scale

Size: 0.19 MB

chapter 13|22 pages

Strategies of biological regulation

Size: 1.20 MB

chapter 14|24 pages

On allostery and co-operativity

Size: 1.19 MB

chapter 15|35 pages

Allostery and development of its models

Size: 1.40 MB