ABSTRACT
This chapter summarizes knowledge of the biological functions of Sho-saiko-to as it relates to fibrogenesis in the liver. Sho-saiko-to has been shown to improve liver function, as well as to alleviate the subjective symptoms associated with chronic liver disease, such as nausea, vomiting, and digestive discomfort. In an animal model of endotoxemia, the preadministration of Sho-saiko-to was found to significantly increase the activity of superoxide dismutase and glutathione peroxidase, suggesting that Sho-saiko-to acts by protecting against plasma membrane damage by reactive oxygen species such as free radicals. Although herbal medicines are thought to be safe drugs, a complicating factor, which has caused physicians and patients to lose confidence in the safety of Sho-saiko-to, is the development of severe interstitial pneumonia associated with its use, particularly when it is used in combination with interferon in treating some Japanese patients with chronic hepatitis C.
