ABSTRACT
I. INTRODUCTION Official guidelines and current textbooks define bioavailability as the rate and extent to which the active ingredient or therapeutic moiety is absorbed from the drug product and becomes available at the site of action. From this, bioequivalence is defined as the absence of a significant difference in bioavailability between pharmaceutical equivalents or pharmaceutical alternatives, the latter being dosage forms in which the chemical form, dosage form type, or strength of the therapeutic moiety, differ.
