ABSTRACT
Efficient preparation of polysaccharide, of which structure is well-defined, by enzyme-catalyzed synthetic reactions is one of the most attractive subjects in the field of fine polymer synthesis. K. Kobayashi et al. synthesized graft copolymers having amylose as side chains by the combination of radical polymerization and enzyme-catalyzed polymerization by the use of phosphorylase. The synthesis of sulfated alkyl oligosaccharides with potent inhibitory effects on HIV infection has been investigated. K. Katsuraya and T. Uryu et al. examined the anti-HIV activity and anticoagulant activity of several sulfated alkyl laminari-oligosaccharides which were individually prepared by use of five pure oligosaccharides of laminari-pentaose through laminari-nonaose, and the relationship between the chemical structure and biological activities. Self-aggregate of hydrophobized water soluble polymer is of great interest with respect to understanding the behavior of biological macromolecules in living system. It has been reported that hydrophobized polysaccharides form nanosize hydrogels upon self-aggregation.
