This chapter focuses on the broader political context in which LGBTI TANs operate. Indeed, TANs do not work in a vacuum; rather their advocacy is influenced by other NGOs and states, for better or for worse. Therefore, LGBTI gatekeeper NGOs frame LGBTI issues in a way that maximises their political opportunities and minimises resistance from conservative/religious opponents of LGBTI people’s rights. LGBTI gatekeeper NGOs use mainly, although not exclusively, a prohibition of discrimination on the grounds of SOGII framework because it is a practical framework and it matches a well-consolidated human rights principle. Despite LGBTI gatekeeper NGOs’ best efforts, the prohibition of discrimination is still perceived as provocative by some conservative/religious TANs and states that use a ‘slippery slope’ argument.