This chapter focuses on the issue of psychopathology from the point of view of care eliciting. It examines how amplified care-eliciting biosocial incentives set up the individual for suffering. New theories and integrations, concerning self-other relationships in psychopathology, are appearing constantly. Two very important theories are Ryle's cognitive-analytic integration and Heard and Lake's development of attachment theory and object relations theory. The chapter examines developmental issues pertaining to early infant/child relationships and theories of vulnerability relating to an individual's sociotropic needs or needs for a mediator, and also focuses on some theories of anxiety and depression. Beck et al. have given a number of distinctions between anxiety and depression. Arieti and Bemporad have articulated a theory of depression which distinguishes two types of depressive vulnerability. These are labelled "dominant other" and "dominant goal". Gunderson and Elliott have outlined some hypotheses of the relationship between personality disorders and affective disorders.