ABSTRACT
Orthostatic hypotension Carpal tunnel syndrome (20% of patients) Peripheral neuropathy Posttraumatic purpura (e.g., postproctoscopic periorbital purpura)
• Amyloid involvement of the gastrointestinal tract may cause malabsorption and intestinal dysmotility, the latter of which may cause diarrhea, constipation, megacolon, and fecal incontinence
• Congo red staining of an aspirated sample of subcutaneous fat shows amyloid fibrils in 90% to 95% of patients, whereas rectal biopsy shows amyloid in 70% to 85% of patients
