ABSTRACT
Among the parameters responsible for drug release from the system under study, the diffusion coefficient and solubility in water are the most important. The permeability of the partially degraded copolymer of MAn-VAc to the different drugs has been studied (44). Table 4 gives a list of these drugs and their solubility in water, and Table 5 illustrates the dependencies of the diffusion coefficients of these drugs on the time of degradation. The diffusion coefficient in the initial copolymer corresponds to the diffusion coefficient of the drug in pure water, and the dependence, as a whole, is the dependence of the diffusion coefficient of the drug on the concentration of water in the polymer, which should be put in the model [see Eq. (11)].
