Miscommunication is a major reason for misunderstandings or things quickly going wrong. A single instance of miscommunication can undo numerous hours of proper communication. Michelle Boyea, Vice President of McKesson Pharmaceuticals, said: the best way to communicate effectively is to keep it simple. Communication is about building relationships and engaging with one another. As a leader people are responsible for effective communication. Effective leaders work to create an environment among the entire organization that encourages dialogue among peers in an effort to improve work production. In some countries, business leaders tackle numerous agenda items at one time, while in other countries they take items one at a time and will not go onto the next one until the previous one is resolved. Recognizing the nonverbal cues others are giving off can allow for more effective and productive communication. Carmazzi is a proponent of the Colored Brain Communication model, which focuses on the ability to manage personal expectations.