ABSTRACT
This chapter discusses the field of the mathematical and computational modeling of endogenous transepithelial potential. It reviews some modeling techniques that have the potential to simulate realistic wound-induced electric signals. The chapter explains a methodology that can help a beginner start building their own computational model for the endogenous electrical signals generated by a wound in any epithelial system. The temporal and spatial patterns of the endogenous wound generated electric signals needs also to be quantified with respect to the wound stage, size, and shape. Axial transport of all ions will combine with the radial fluxes due to different transport mechanisms in the apical and basolateral membrane to form the endogenous electric currents in the case of an epithelial wound. Natural wound healing is a highly complicated process that consists of several timed stages of cell signaling, migration, and proliferation. The endogenous electric field was also found to have bacteriostatic effect by intervening bacterial proliferation.
