A multi-stakeholder partnership (MSP) brings together various stakeholders willing to contribute to sustainable development. In themselves, MSPs are complex; there is no one-size-fits-all approach concerning its design and operation. This chapter gives practical tips along the process of (i) initiating, (ii) institutionalizing and (iii) assessing the impact of MSPs. The tips on the first steps in MSPs elaborate how to find potential partners, initiate a partnership and tackle challenges along the way (i). Once an MSP is operating, its institutionalization helps to define a governance structure, general rules and to approach the question of funding (ii). Lastly, the chapter identifies the potential impact of MSPs and ways of impact assessment; illustrated using a case study on sustainable tuna fisheries in the Philippines (iii).