ABSTRACT
It is now recognized that late-phase allergic reactions (LPRs) undoubtedly contribute substantially to the clinical symptoms of various allergic disease including asthma, allergic rhinitis, urticaria, and atopic dermatitis. The recognition of the LPR and its associated tissue inflammatory response has conceptually changed therapeutic approaches to allergic diseases. With the aid of various animal models and more extensive analysis in humans, a more comprehensive understanding of the LPR, specifically as it relates to the lower airway, has now emerged.
