ABSTRACT
The present entry deals with the employment of some hydrophilic polymers known for their bioactive properties as enabling excipients of novel therapeutic systems intended for wound healing. After a preliminary description of wound classification and the healing process, the mechanisms underlying tissue repairing properties of chitosan, hyaluronic acid, and chondroitin sulfate have been reviewed. Beside these biopolymers, particular attention has been focused on the use of hemoderivatives, namely platelet derivatives [platelet-rich plasma, platelet gel, and platelet lysate (PL)] in the treatment of epithelial (cutaneous, corneal, and mucosal) lesions. Since the authors have gained experience on the association of the above-mentioned biopolymers with PL, an overview of the newly developed platforms for the delivery of such platelet derivative in skin and corneal lesions is reported.
