ABSTRACT
Pharmaceutical drug delivery systems have become very sophisticated to comply with unique drug delivery requirements, in vivo imaging needs, and delivery of genes and other large molecules. With increasing complexity of the drug delivery systems, the need for novel biomaterials to achieve successful formulations has become imperative. This article reviews latest nanoparticle-based drug delivery systems such as drug- polymer conjugates, solid lipid nanoparticles, liposomes, lipid–polymer hybrids, and dendrimers. The review of the formulations and the clinical trials shows how biomaterials have evolved from simple basic structures to very complex structures to satisfy the formulation needs.
