ABSTRACT
In this entry, two types of supramolecular assembling phenomena will be discussed in relation to gene mutation assay, which is one of the most important areas of biomedical sensing and diagnosis. First, the entry will review DNA-carrying colloidal nanoparticles prepared from DNA-PNIPAAm graft copolymer through supramolecular assembly. Then, it will discuss DNA-carrying nanoparticles assembled in the presence of complementary DNA to yield visibly detectable aggregates due to cross-linking or colloidal stability change.
