ABSTRACT
To minimize variations in raw material characteristics, ensure reproducibility of results during preformulation, and correctly judge the cause of instability and poor performance of a dosage form, it is essential to recognize the importance of changes in crystal surface appearance and habit of pharmaceutical powders. This entry reviews the factors that influence crystal habit, the significance of crystal habit in dosage form performance, and how the study of changes in crystal habit and the polymorphic state at critical processing stages is crucial for maintaining uniformity in raw material characteristics.
