ABSTRACT
The term “proteome” refers to all proteins produced by a species, much as the genome is the entire set of genes. There is an increasing interest in proteomic technologies now because DNA sequence information provides only a static snapshot of the various ways in which the cell might use its proteins whereas the life of the cell is a dynamic process. This entry discusses the pharmaceutical applications of proteomics, the basis of this approach in drug discovery, the role of proteomics in targeting disease pathways, and a chemical proteomics approach to drug discovery.
