ABSTRACT
Oxidative stress is implicated in many diseases related to lifestyle and aging. Therefore, antioxidant protection attracts much attention against these diseases (1-3). The brain is essentially vulnerable against oxidative abuse because of its poor anitoxidant defense including low level of antioxidant small molecules and also antioxidant enzymes (4). Moreover, the tissue is rich in sensitive cellular components toward oxidative abuse such as polyunsaturated fatty acids and catecholamine. Indeed accumulated oxidative injury of cellular components results in many brain disorders including Alzheimer’s and Parkinson’s diseases. Therefore, protection of cerebral oxidative injury is important for the quality of life in our society. The antioxidant approach is attractive for the treatment of cerebral disorders including dementia, and many trials have been reported to prevent cerebral oxidative tissue injury using natural and artificial small antioxidants such as vitamins E, lazaroid, and lipoic acid, as well as antioxidant enzymes (5-7).
