ABSTRACT

Free radicals have received increasing attention as their roles in the pathophysiology of many diseases of the nervous system have become evident. This chapter will explore some of the target sites of free radicals in neural systems. However, the consequences of free radical exposure depend not only on the target but also on their functional integration and secondary effects. The subject is further complicated by the inherent protective systems that the body has developed to cope with ubiquitous free radicals. This chapter is not meant as a comprehensive review of the subject but rather as an overview of the issues involved in understanding the complexity of problem.