ABSTRACT
CONTENTS 5.1 Introduction ..................................................................................................60 5.2 Rationale for and Genesis of Synthetic Absorbable
Cyanoacrylate-Based Systems ...................................................................61 5.3 Unique Properties of Absorbable Tissue Adhesives and
Evolution of the Cyanoacrylate-Based Systems .....................................62 5.4 Evolution of the Evaluation Methods for Synthetic
Absorbable Tissue Adhesives ....................................................................64 5.4.1 Characterization of Uncured Adhesive Formulations ..............64 5.4.2 Effect of pH on the Molecular Weight and Thermal
Properties of Absorbable Tissue Adhesives................................64 5.4.3 In Vitro Evaluation of the Adhesive Joint Strength
and Pertinent Data ..........................................................................66 5.4.4 Evaluation of the In Vitro and In Vivo Absorption
Profiles and Typical Results ..........................................................69 5.4.4.1 In Vitro Absorption ...........................................................69 5.4.4.2 Direct Evaluation of In Vivo Absorption.......................69 5.4.4.3 Indirect Evaluation of In Vivo Absorption
Using Radiolabeled Tissue Adhesive ............................70 5.4.5 Evaluation of In Vivo Performance of Absorbable
Tissue Adhesives .............................................................................72 5.4.5.1 Comparative Evaluation of V-200 Tissue
Adhesive Formulations against Suture and Staple Controls ..................................................................72
