ABSTRACT

Transformation Assay . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 9.6 Simultaneous Chemical Induction of Morphological Transformation, Mutation, and

Chromosomal Aberrations in C3H/10T1/2 Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 210 9.7 Molecular Biology of Chemically Induced Morphological and Neoplastic Cell

Transformation in C3H/10T1/2 Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215

The topic of chemical transformation in cultured rodent cells has been reviewed previously [1-5]. Our purpose here is to update and review the utility of the currently used cell transformation assays

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in C3H/10T1/2 Cl 8 mouse embryo cells for detecting chemical carcinogens and for studying the molecular mechanisms of chemically induced morphological and neoplastic cell transformation to gain insight into the molecular mechanisms of chemical carcinogenesis.