ABSTRACT
Rheology is also involved in the mixing and flow of materials, their packaging into containers, and their removal prior to use. In the field of pharmacy, micromertics has become an important area of study because it influences a large number of parameters in research, development, and manufacturing of dosage forms such as suspension to be reconstituted, tablet, and capsule. The content uniformity of a drug in a solid dosage form, particularly low dose and highly potent drugs, can also be affected by the particle size and size distribution of a drug. The simplest definition of particle size diameters is based on the assumption that particles are spherical. Mode diameter represents the particle size occurring most frequently in a sample; it is used far less frequently than mean and median diameter. The chapter discusses microscopy, sieving, and sedimentation methods. The size distribution and the surface area of powders are the two fundamental properties of any collection of particles.
