ABSTRACT
There are many fusion cell lines currently utilized for monoclonal antibody-secreting hybridoma production. They are all derived from mouse, rat, or human cell lines. Human hybridomas are still at an early stage of development. On the contrary, both mouse and rat systems are widely used. The mouse system is historically the first to have been developed by Köhler and Milstein 1 as a method for the production of monoclonal antibodies of predefined specificity, and several mouse fusion lines are available (Table 1).
